In this enlightening YouTube video presented by The Matilda Centre, the complex and potentially perilous world of polysubstance use is explored, with a particular focus on the concurrent use of crystal methamphetamine (commonly referred to as ‘ice’) and other substances. Polysubstance use denotes the simultaneous or successive ingestion of multiple drugs, an action that can trigger unpredictable and severe repercussions on an individual’s physical and mental wellbeing. It is underscored in the video that the amalgamation of ice with other substances significantly heightens the risk of overdose, in addition to leading to detrimental health effects, both mental and physical. The pairing of ice with stimulant drugs, for instance, can result in a sharp increase in heart rate and body temperature. Conversely, when combined with depressants such as alcohol, cannabis, or heroin, ice may precipitate heart complications. Reasons for such polydrug use can vary, ranging from the desire to augment or prolong the euphoric impact of ice, to peer pressure, and even as a strategy to alleviate the harsh side effects experienced during withdrawal. However, the video also emphasizes that the harm from ice use can be mitigated through specific strategies. These include limiting the number of drugs consumed concurrently, refraining from using ice when alone, ensuring proper hydration and sufficient rest, adopting safe injection practices, and gaining a solid understanding of the signs of an impending overdose.